Interferometric speckle visibility spectroscopy
AssigneeCalifornia Institute of Technology
InventorsJoshua Brake, Jian Xu, Changhuei Yang
Life of this patent
Estimating the term…
Abstract
Interferometric speckle visibility spectroscopy methods, systems, and non-transitory computer readable media for recovering sample speckle field data or a speckle field pattern from an off-axis interferogram recorded by one or more sensors over an exposure time and determining sample dynamics of a sample being analyzed from speckle statistics of the speckle field data or the speckle field pattern.
Claims44
1-19. (canceled)
A method for monitoring cerebral hemodynamics, the method comprising:
- (i) providing laser light to a skull;
- (ii) recording an image with a speckle pattern over an exposure time based on light passing through brain tissue within the skull;
- (iii) determining one or more speckle statistics of the image;
- and
- (iv) determining cerebral hemodynamics of the brain tissue based at least in part on the one or more speckle statistics.
A system for monitoring cerebral hemodynamics, the system comprising:
- one or more optical systems configured to provide laser light to a skull and collect light passing through brain tissue being imaged within the skull;
- and
- one or more sensors configured to record one or more images based on the light passing through the brain tissue, wherein each image comprises a speckle pattern recorded over an exposure time.
A method for monitoring cerebral hemodynamics, the method comprising:
- (i) determining one or more speckle statistics of an image, the image comprising a speckle pattern recorded by one or more sensors over an exposure time based on light passing through brain tissue within a skull illuminated by laser light;
- and
- (ii) determining cerebral hemodynamics of the brain tissue based at least in part on the one or more speckle statistics.
A non-transitory computer readable media for monitoring cerebral dynamics, the non-transitory computer readable media comprising program instructions, wherein the program instructions, when executed by one or more processors, are configured to cause the one or more processors to execute operations comprising:
- (i) determining one or more speckle statistics of an image, the image comprising a speckle pattern recorded by one or more sensors over an exposure time based on light passing through brain tissue within a skull illuminated by laser light;
- and
- (ii) determining cerebral hemodynamics of the brain tissue based at least in part on the one or more speckle statistics.
Dependencies are inferred from the claim text.