Polymeric biomaterials derived from phenolic monomers and their medical uses
AssigneeRutgers, The State University of New Jersey
InventorsJoachim B. Kohn, Durgadas Bolikal
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Abstract
The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.
Claims10
1-11. (canceled)
A biocompatible copolymer consisting of diphenolic backbone recurring units consisting of diphenolic recurring units selected from the group consisting of diphenolic recurring units of formula:
- wherein:
- y1 and y2 are independently 0, 1, 2, 3, or 4;
- m and n are each independently an integer in the range of 1 to 12;
- X1 and X2, at each occurrence, are each independently bromine (Br) or iodine (I);
- L1 is selected from the group consisting of a bond, oxygen (—O—), and —R4—C(O)—O—;
- and
- L4 is a linking group selected from the group consisting of a bond and optionally substituted phenoxy of formula —C6H4—O—;
- wherein the bromine or iodine substitution is in the backbone of the copolymer;
- and
- wherein the copolymer is a condensation copolymer;
- L2 is a bond or —R8—C(O)—;
- and
- R8 is selected from the group consisting of a bond, C1-C30 alkylene, C2-C30 alkenylene, C2-C30 alkynylene, C1-C30 heteroalkylene, C2-C30 heteroalkenylene, C2-C30 heteroalkynylene, C7-C30 heteroalkylarylene, C8-C30 heteroalkenylarylene, C8-C30 heteroalkynylarylene, C7-C30 alkylarylene, C8-C30 alkenylarylene, C8-C30 alkynylarylene, and C2-C30 heteroarylene.
Dependencies are inferred from the claim text.