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AssigneeTechnion Research & Development Foundation Limited
InventorsPhilippa MELAMED, Lilach Pnueli POLINSKY
Estimating the term…
Compositions and methods for treating a medical condition are provided. Accordingly, there is provided a composition comprising a polypeptide comprising a GnRH receptor binding protein and a polynucleotide coding a therapeutic agent, wherein said polypeptide is in association with said polynucleotide via a linker comprising a cleavage motif that can be cleaved by a proteolytic enzyme secreted by a cell expressing said GnRH receptor. Also provided is a nucleic acid construct comprising a nucleic acid sequence encoding a fusion protein comprising a DNA binding domain (DBD) of a transcription factor that binds a regulatory region of a gonadotropin gene attached to a chromatin modifying domain that represses transcription upon association with the DBD. Also provided are methods of use thereof.
A composition comprising a polypeptide comprising a GnRH receptor binding protein and a polynucleotide coding a therapeutic agent, wherein said polypeptide is in association with said polynucleotide via a linker comprising a cleavage motif that can be cleaved by a proteolytic enzyme secreted by a cell expressing said GnRH receptor.
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A nucleic acid construct comprising a nucleic acid sequence encoding a fusion protein comprising a DNA binding domain (DBD) of a transcription factor that binds a regulatory region of a gonadotropin gene attached to a chromatin modifying domain that represses transcription upon association with said DBD.
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A composition comprising a GnRH receptor binding protein attached to a cell penetrating peptide by a linker comprising a cleavage motif that can be cleaved by PACE4, wherein said cell penetrating peptide is attached to- or encapsulates a nucleic acid construct encoding a fusion protein comprising a DNA binding domain (DBD) of Sf-1 attached to a KRAB domain.
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Dependencies are inferred from the claim text.