Self-amplifying messenger rna
AssigneeGlaxosmithkline Biologicals SA
InventorsGiulietta MARUGGI, Jason William WESTERBECK, Dong YU
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Abstract
Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes an interferon effector.
Claims38
A composition comprising a self-replicating messenger ribonucleic acid (mRNA) comprising a construct encoding a first heterologous polypeptide interferon effector that suppresses an interferon response, wherein the heterologous polypeptide interferon effector is
- (a) VP35, or a variant or fragment thereof;
- or
- (b) N, or a variant or fragment thereof;
- wherein the self-replicating mRNA further comprises a construct encoding a polypeptide selected from the group consisting of:
- a polypeptide antigen;
- an antigen-binding polypeptide;
- an immune-modulatory polypeptide;
- or a therapeutic polypeptide.
A composition comprising a self-replicating mRNA comprising a construct encoding a heterologous polypeptide interferon effector that enhances an interferon response, wherein the heterologous polypeptide interferon effector is PB1-F2, or a variant or fragment thereof, wherein the self-replicating mRNA further comprises a construct encoding a polypeptide selected from the group consisting of:
- a polypeptide antigen;
- an antigen-binding polypeptide;
- an immune-modulatory polypeptide;
- or a therapeutic polypeptide.
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A composition comprising a liposome comprising a mRNA encoding VP35, or a variant or fragment thereof.
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Dependencies are inferred from the claim text.