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OwnerJuhyun Lee, Young Ju Kim +11inventors
InventorsJuhyun Lee, Young Ju Kim, Jun Kim, Hanna Kim, Jong Ryoul Choi, Jae Hong Kweon, Dongkyu Kim, Yeji Byeon, Hyunwoo Shin, Daseul Yoon, Ye-Lim Lee, Seung Hee Jung, Do Seok Hwang
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The present invention relates to novel salts of a heterocyclic compound as a protein kinase inhibitor and uses thereof. The novel salts are superb in terms of water solubility and physical and chemical stability and thus can be usefully employed in formulating medicinal products. In addition, the heterocyclic compound or the salts thereof can effectively treat and prevent atopic dermatitis and inflammatory bowel disease.
An organic acid salt of N-(4-(1-(2-cyanoacetyl)-3-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)cyclopropanecarboxamide, wherein the organic acid salt is hydrochloride salt, hydrobromide salt, phosphate salt, camsylate salt, oxalate salt, mesylate salt, or napadisylate salt.
A composition for treating or preventing atopic dermatitis, which comprises N-(4-(1-(2-cyanoacetyl)-3-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)cyclopropanecarboxamide or pharmaceutically acceptable salts thereof as an effective ingredient.
A composition for treating or preventing inflammatory bowel disease, which comprises N-(4-(1-(2-cyanoacetyl)-3-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)cyclopropanecarboxamide or pharmaceutically acceptable salts thereof as an effective ingredient.
A method for treating or preventing atopic dermatitis, the method comprising:
A method for treating or preventing inflammatory bowel disease, the method comprising:
A use of N-(4-(1-(2-cyanoacetyl)-3-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)cyclopropanecarboxamide or pharmaceutically acceptable salts thereof for treating or preventing atopic dermatitis.
A use of N-(4-(1-(2-cyanoacetyl)-3-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)cyclopropanecarboxamide or pharmaceutically acceptable salts thereof for treating or preventing inflammatory bowel disease.
A use of N-(4-(1-(2-cyanoacetyl)-3-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)cyclopropanecarboxamide or pharmaceutically acceptable salts thereof for preparing a medicament for treating or preventing atopic dermatitis.
A use of N-(4-(1-(2-cyanoacetyl)-3-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)cyclopropanecarboxamide or pharmaceutically acceptable salts thereof for preparing a medicament for treating or preventing inflammatory bowel disease.
Dependencies are inferred from the claim text.