Tangential Filtration Elements and Filtration Devices and Methods Of Use

Abstract

In some embodiments thereof, the present invention describes TFF (Tangential Flow Filtration) filtration devices that utilize tubular membranes for the separation of cells and particles. These devices encompass several innovative features, including the use of membrane tubes with either circular or non-circular cross-sections. These tubes are closely surrounded by both tube housing and filter housing to regulate the pressure of the liquid exiting the filter housing. Additionally, the membrane tubes may feature internal cores within their lumens and/or structures along their inner walls. These internal features serve to regulate flow patterns and pressures within the tubes. One notable aspect of this invention is the inclusion of features on the tube housing or tube core that effectively regulate pressure resistance and feed flow patterns. These features lead to a reduction in the required recirculation rate and contribute to improved transmembrane pressure profiles, making these membrane filters highly effective for cell retention in cell culture and other applications. The patent also introduces various filter designs that incorporate tubular membranes into TFF filtration devices to achieve multiple goals, including a more consistent TMP (Transmembrane Pressure) profile for efficient separation, reduced recirculation rates to generate adequate shear rates, higher packing densities of membrane surface areas within the same filter design, and enhanced manufacturability and recyclability of the filters. Overall, this invention represents a significant advancement in the field of TFF filtration, offering innovative solutions for a wide range of applications in the separation of cells and particles.

Dependencies are inferred from the claim text.