Dimerization strategies and compounds for molecular imaging and/or radioimmunotherapy
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsDexing ZENG, Lingyi SUN, Yongkang GAI
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Abstract
The present invention provides a multivalent compound for targeted molecular imaging and/or targeted drug delivery, wherein two components or targeting molecules each interacts with one or more biomarkers on a cell. The present invention further provides a multifunctional chelator to combine the targeting molecules. The present invention also provides an in vitro high-throughput screening assay to determine the length of the spacer molecules. The present invention also relates to compounds/probes, kits and methods for use in targeted molecular imaging and/or targeted drug delivery.
Claims23
1-13. (canceled)
A drug delivery compound for the delivery of a therapeutically effective amount of an active agent to a subject in need of the active agent comprising:
- a first peptide binding to a first biomarker and a chelator;
- and
- a second peptide binding to a second biomarker.
15-66. (canceled)
(canceled)
Dependencies are inferred from the claim text.