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US 2024/0299582 A1Published application
Viral delivery of a sialidase to treat cancer
AssigneeUniversitäT Basel
InventorsHeinz LÄUBLI, Natalia RODRIGUES MANTUANO
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Abstract
The present invention relates to adenovirus-associated virus comprising an influenza-derived neuraminidase transgene, used alone or together with an immune checkpoint inhibitor to treat a patient diagnosed with a solid cancer.
Claims15
An adeno-associated virus comprising a transgene encoding a sialidase (AAV-Sia), wherein the sialidase is derived from the influenza virus, for use for the treatment, or for the prevention of recurrence of cancer in a patient in need thereof.
Dependencies are inferred from the claim text.