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AssigneeMdimune Inc.
InventorsShin Gyu BAE, Seung Wook OH, Jung Eun PARK, Sung Soo PARK, Ye Rim KWON, Hui Chong LAU, Jin Hee PARK
Estimating the term…
The present invention relates to cell-derived vesicles with increased cellular uptake capacity and a method for producing same. The cell-derived vesicles of the present invention are produced by migrating cells to micropores, and exhibit the characteristic of expressing a protein marker that is different from that of exosomes naturally secreted by cells. The cell-derived vesicles with increased cellular uptake capacity, according to the present invention, have remarkably superior cellular uptake capacity as compared to natural exosomes secreted by cells, and thus can be effectively used to deliver various active substances, such as drugs and marker substances, into target cells.
A method for producing cell-derived vesicles (CDVs) with increased cellular uptake capacity comprising producing the cell-derived vesicles by migrating a sample containing cells into micropores.
Cell-derived vesicles with increased cellular uptake capacity characterized by increasing expression of at least one membrane surface protein marker selected from the group consisting of CD63 and LAMP1 as compared to cell-secreted exosomes.
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Dependencies are inferred from the claim text.