Immunogenic composition
AssigneeGlaxosmithkline Biologicals SA
InventorsChristiane Marie-Paule Simone Jeanne Feron, Sandra Giannini
Life of this patent
Estimating the term…
Abstract
The present invention discloses a recombinant bacteriophage comprising a phage genome polynucleotide including a gene encoding a heterologous antigen protein(s) and a killing gene encoding a protein that is capable of killing a host bacterium. Such a recombinant bacteriophage is designed to prime a subject's immune response and to kill the bacterium that it infects such that the “prime and kill” bacteriophage provides two lines of protection against infectious disease.
Claims20
A recombinant bacteriophage genome polynucleotide comprising a heterologous antigen gene encoding a heterologous antigen protein and a killing gene encoding a protein that is capable of killing a host bacterium, wherein the heterologous antigen protein, after expression is released into the cytoplasm of a bacterium infected by the bacteriophage.
Dependencies are inferred from the claim text.