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US 2024/0294972 A1Published application
Enrichment of nucleic acid targets
AssigneeQuantum-Si Incorporated
InventorsAndrea Marziali, Milenko Despotovic, Joel Pel
Life of this patent
Estimating the term…
Abstract
Methods and apparatus providing for the isolation of an unknown mutation from a sample comprising wild type nucleic acids and mutated nucleic acids through the application of time-varying driving fields and periodically varying mobility-altering fields to the sample within in an affinity matrix.
Claims21
1-20. (canceled)
A method for isolating a target molecule in a sample, the method comprising:
- applying a time-varying driving field to the sample in the presence of affinity probes, the probes having a binding affinity for the target molecule;
- applying a periodically varying, mobility-altering field that modifies the binding affinity;
- wherein application of the time-varying driving field and the periodically varying, mobility-altering field isolates the target molecule from the sample.
A method for isolating a charged target molecule in a sample using scodaphoresis, the method comprising:
- applying a time-varying electrical field to the sample;
- applying a periodically varying, mobility-altering field;
- wherein application of the time-varying electrical field and the periodically varying, mobility-altering field isolates the charged target molecule from the sample.
Dependencies are inferred from the claim text.