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AssigneeCentivax, Inc.
InventorsJacob E. Glanville, Timothy Paul Friede, David Tsao, Sindy Andrea Liao Chan, I-Chieh Wang
Estimating the term…
This disclosure provides antibodies and antigen-binding fragments that can be administered to a subject that has been bitten by a venomous snake. Antibodies and antigen-binding fragments herein can be capable of treating or curing the subject and may provide protection against snake venom for up to several weeks. A combination or population of antibodies and antigen-binding fragments can be administered to the subject where the type of snake is not known or where a subject has been bitten by more than one species of snake. This disclosure further provides methods for identification of such broadly-neutralizing antibodies.
A method of treating a subject who suffers from an envenomation, comprising administering to the subject a composition comprising an effective amount of a broadly-neutralizing anti-venom that comprises one or more antibodies or one or more antigen-binding fragments.
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A broadly-neutralizing anti-venom composition comprising one or more an anti-venom antibody(ies) or antigen-binding fragment(s) that selectively bind(s) to one or more toxin(s) from one or more species of snake(s).
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A method of identifying a broadly-neutralizing antibody or antigen-binding fragment that selectively binds to 2 or more snake venom toxins belonging to a family of homologous antigens, the method comprising
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Dependencies are inferred from the claim text.