USP9X Inhibitors

A compound represented by Formula (IV):

• and Z is H, a substituted or unsubstituted alkyl, —C(O)CH3, or Z is:
• Formula (Z), Resulting in the Formula as Below:
• Wherein m, o, p, s, and r are each independently selected from 0, 1, 2, 3, 4, or 5.
• R1, R4, R6, R7, R9, R10 and R11 are each independently selected from H, D, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl;
• alternatively, when r is 1, R10 and R11 together with the carbons to which they are attached form a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl;
• R2 and R5 are each independently selected from H, 2H, and substituted or unsubstituted alkyl;
• alternatively, R1 and R2 together with the carbon and nitrogen to which they are respectively attached form a substituted or unsubstituted heteroaryl, or a substituted or unsubstituted heterocycloalkyl;
• alternatively, when m is 1, R4 and R5 together with the carbon and nitrogen to which they are respectively attached form a substituted or unsubstituted heteroaryl, or a substituted or unsubstituted heterocycloalkyl;
• R3 is selected from H, D, halogen, substituted or unsubstituted alkyl;
• R5 is selected from H, D, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, —ORA, —CN, —NRBRC, —NRDC(O)RE—CO2RF, and —C(O)NRGRH, wherein each of RA, RB, RC, RD, RE, RF, RG, and RH is independently selected from H, D, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl;
• or RB and RC or RG and RH can be taken together with the nitrogen to which they are attached to form a substituted or unsubstituted 5, 6, 7, or 8 membered ring;
• alternatively, wherein when p is 1, R7 and R5 together with the carbons to which they are attached form a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl;
• X1, X2, X3, X4, X5, and X7 are each independently selected from absent, substituted or unsubstituted alkylene, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, —NRIC(O)—, —C(O)NRJ—, —O—, —OC(O)—, —C(O)O—, —NRKC(O)NRK—, —C(RL)═C(RM), —NRL—CRMRN—, —CRMRN—NRL—, wherein each of RI, RJ, RK, RL, RM and RN is independently selected from H, D, substituted or unsubstituted alkyl;
• alternatively, when X7 is —C(RL)═C(RM)—, or —NRL—CRMRN—, RL and X6 or R9 together with the atoms to which they are respectively attached form a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, wherein the RN in —NRL—CRMRN—can be absent and the carbon atom is covalently bound to the moiety on the right via a double bond;
• alternatively, when r is 1, X7 is —C(RL)═C(RM)—, —NRL—CRMRN—, R10, R11, X7, RL, and X6 or R9 together with the atoms to which they are respectively attached form a substituted or unsubstituted bicyclic fused ring system that contains zero, one or more heteroatoms such as N, O, or S.
• X6 is selected from H, D, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, —ORA, —CN, —NRBRC, —NRDC(O)RE, —CO2RF, —C(O)NRGRH, or X6 is —(CHR18)q—X8-L-R19;
• wherein X5 is absent, —CONH—, —NHC(O)—, —N(CH3)—, —OC(O)—, —C(O)O—, —O—, or —NHC(O)NH—;
• q is 0, 1, 2, 3, or 4;
• R18 is selected from H, halogen, a substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, —ORA, —CN, —NRBRC, —NRDC(O)RE, —CO2RF, and —C(O)NRGRH;
• R19 is selected from H, halogen, a substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, —ORA, —CN, —NRBRC, —NRDC(O)RE, —CO2RF, —C(O)NRGRH—C1-6 alkyl-NRBRC, —C1-alkyl-NRDC(O)RE, —C146 alkyl-CO2RF, —C1-alkyl-C(O)NRGRH;
• or R19 is:
• L is absent or a linker group —(CH2)nCRORP(CH2)n—, wherein RO and RP are each independently selected from H, 2H, substituted or unsubstituted alkyl;
• or RO and RP together with the carbon to which they are attached form a substituted or unsubstituted C3—C6 cycloalkyl, or a substituted or unsubstituted 3- to 6-membered heterocyclic ring;
• and wherein each n is independently 0, 1, or 2;
• Alternatively, when L is absent, R18/X8/R19 together form a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, and substituted or unsubstituted heterocycloalkyl.