Branched oligonucleotides

A di-branched oligonucleotide compound comprising two siRNA molecules covalently bound to one another by way of a linker,

• wherein:
• (a) each siRNA molecule comprises an antisense strand having complementarity to a target gene and a sense strand having complementarity to the antisense strand;
• (b) from 80% to 100% of the nucleotides in each siRNA molecule are chemically modified;
• and
• (c) each antisense strand and each sense strand are, independently, from 15 to 30 nucleotides in length.