Contact lens for photodynamic inactivation of germs, product and method of treating fungal keratitis by applying the same

A product of contact lens for photodynamic inactivation of germs, comprising:

• a packaging structure, comprising:
• an accommodating portion, comprising a groove portion and a flat portion surrounding the groove portion;
• and
• a cover sheet, removably attached to the flat portion and disclosing the groove portion;
• a photoactive solution, accommodated in the groove portion, wherein the photoactive solution comprises 0.01 wt % to 1.0 wt % rose bengal, 0.01 wt % to 1.0 wt % hydrogen peroxide, and a buffer solution with a balance, and the photoactive solution excludes an antifungal agent;
• and
• a contact lens, accommodated in the groove portion and submerged in the photoactive solution, wherein the contact lens is a hydrogel or a silicone hydrogel, and
• after the contact lens is exposed to white light for 0.01 hour to 16 hours, the photoactive solution continuously released by the contact lens produces singlet oxygen and reactive oxygen species, thereby inhibiting growth and activity of fungi.

A method of treating fungal keratitis by applying a contact lens for photodynamic inactivation of germs, comprising:

• submerging a contact lens in a photoactive solution, wherein the contact lens is a hydrogel or a silicone hydrogel, and the photoactive solution comprises 0.01 wt % to 1.0 wt % rose bengal, 0.01 wt % to 1.0 wt % hydrogen peroxide and a buffer solution with a balance;
• applying the contact lens on an infected eye;
• and
• exposing the infected eye applied with the contact lens to white light for 0.01 hour to 16 hours, wherein the photoactive solution continuously released by the contact lens produces singlet oxygen and reactive oxygen species, thereby inhibiting growth and activity of fungi, and the photoactive solution excludes an antifungal agent.