Fibroblast delivery of tumor inhibitory agents
AssigneeFigene, LLC
InventorsPete O'Heeron, Thomas Ichim
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Abstract
Embodiments of the disclosure encompass methods and compositions for treatment of cancer utilizing fibroblasts that have been modified to enhance their ability to deliver one or more anti-cancer agents to an individual in need thereof. In particular embodiments, the fibroblasts have been modified to express one or more chemokine receptors and/or have been exposed to hypoxia to enhance their ability to home to cancer cells. In specific cases the modified fibroblasts are engineered to encompass an oncolytic virus as a tumor inhibitory agent.
Claims32
A method of preparing fibroblasts as anti-cancer delivery compositions, comprising the steps of:
- (a) optionally modifying fibroblasts to enhance activity of homing to cancer cells or tissue comprising cancer cells;
- and
- (b) manipulating fibroblasts to comprise one or more tumor inhibitory agents.
The method of any one of claims 1-11, wherein the tumor inhibitory agent is a virus.
The method of claim 12, wherein the virus is an oncolytic virus or tumor trophic virus.
An isolated fibroblast or population thereof, comprising:
- (a) an oncolytic virus;
- (b) a vector that encodes one or more tumor inhibitory agents;
- or
- (c) both.
Dependencies are inferred from the claim text.