Stat degraders and uses thereof

A compound of formula I-ddd:

• or a pharmaceutically acceptable salt thereof, wherein:
• X1 is a bivalent moiety selected from a covalent bond, —CR2—, —C(O)—, —C(S)—, —CR(CF3)—, —P(O)OR—, —P(O)R—, —P(O)NR2—, —S(O)—, —S(O)2—, or
• X2 is a carbon atom or silicon atom;
• X3 is a bivalent moiety selected from —CR2—, —NR—, —O—, —S—, or —SiR2—;
• R1 is hydrogen, halogen, —CN, —OR, —SR, —S(O)R, —S(O)2R, —NR2, —P(O)(OR)2, —P(O)NR2OR, —P(O)(NR2)2, —Si(OH)2R, —Si(OH)R2, —SiR3, or an optionally substituted C1-4 aliphatic;
• each R is independently hydrogen, or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated heterocyclic having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or:
• two R groups on the same carbon or nitrogen are optionally taken together with their intervening atoms to form an optionally substituted 4-11 membered saturated or partially unsaturated monocyclic, bicyclic, bridged bicyclic, or spirocyclic carbocyclic or heterocyclic ring having 1-3 heteroatoms, in addition to the carbon or nitrogen from which the two R groups are attached, independently selected from nitrogen, oxygen, and sulfur;
• each R2 is independently hydrogen, R6, halogen, —CN, —NO2, —OR, —SR, —NR2, —SiR3, —S(O)2R, —S(O)2NR2, —S(O)R, —C(O)R, —C(O)OR, —C(O)NR2, —C(O)NROR, —CR2NRC(O)R, —CR2NRC(O)NR2, —OC(O)R, —OC(O)NR2, —OP(O)R2, —OP(O)(OR)2, —OP(O)(OR)NR2, —OP(O)(NR2)2, —NRC(O)OR, —NRC(O)R, —NRC(O)NR2, —NRS(O)2R, —NP(O)R2, —NRP(O)(OR)2, —NRP(O)(OR)NR2, —NRP(O)(NR2)2, or —NRS(O)2R;
• each R6 and RA is independently an optionally substituted group selected from C1-6 aliphatic, phenyl, a 4-7 membered saturated or partially unsaturated carbocyclic or heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• Ring A is a bicyclic or tricyclic ring selected from
• wherein:
• Ring B is a fused ring selected from benzo, 5-6 membered heteroaryl containing 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and a 5 to 7-membered saturated or partially unsaturated carbocyclyl or heterocyclyl with 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• R3 is selected from hydrogen, halogen, —OR, —NR2, or —SR;
• each R4 is independently hydrogen, R6, halogen, —CN, —NO2, —OR, —SR, —NR2, —S(O)2R, —S(O)2NR2, —S(O)R, —C(O)R, —C(O)OR, —C(O)NR2, —C(O)NROR, —OC(O)R, —OC(O)NR2, —NRC(O)OR, —NRC(O)R, —NRC(O)NR2, or —NRS(O)2R;
• R5 is hydrogen, C1-4 aliphatic, or —CN;
• m is 0, 1, 2, 3 or 4;
• L is a covalent bond or a bivalent, saturated or partially unsaturated, straight or branched C1-20 hydrocarbon chain, wherein 0-6 methylene units of L are independently replaced by -Cy-, —O—, —NR—, —CRF—, —CF2—, —C(O)—, —S—, —S(O)—, —S(O)2—, —SiR2—, —Si(OH)R—, —Si(OH)2—, —P(O)OR—, —P(O)R—, or —P(O)NR2—, wherein:
• each -Cy- is independently an optionally substituted bivalent ring selected from phenylenyl, an 8-10 membered bicyclic arylenyl, a 4-7 membered saturated or partially unsaturated carbocyclylenyl, a 4-11 membered saturated or partially unsaturated spiro carbocyclylenyl, an 8-10 membered bicyclic saturated or partially unsaturated carbocyclylenyl, a 4-7 membered saturated or partially unsaturated heterocyclylenyl having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, a 4-11 membered saturated or partially unsaturated spiro heterocyclylenyl having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, an 8-10 membered bicyclic saturated or partially unsaturated heterocyclylenyl having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, a 5-6 membered heteroarylenyl having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or an 8-10 membered bicyclic heteroarylenyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• Rx is hydrogen, RA, —(CR2)1-3OCONR2, or —(CR2)1-3CONR2;
• Ry is hydrogen, RA, or
• L1 is a covalent bond or a bivalent, saturated or partially unsaturated, straight or branched C1-5 hydrocarbon chain, wherein 0-3 methylene units of L′ are independently replaced by —O—, —NR—, —CRF—, —CF2—, —C(O)—, —S—, —S(O)—, or —S(O)2—;
• Ring Z is a ring selected from phenyl, naphthyl, a 5-10 membered heteroaryl containing 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-11 membered saturated or partially unsaturated carbocyclyl or heterocyclyl with 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• Rz is hydrogen, RA, halogen, —CN, —NO2, —OR, —SR, —NR2, —SiR3, —S(O)2R, —S(O)2NR2, —S(O)R, —C(O)R, —C(O)OR, —C(O)NR2, —C(O)NROR, —CR2NRC(O)R, —CR2NRC(O)NR2, —OC(O)R, —OC(O)NR2, —OP(O)R2, —OP(O)(OR)2, —OP(O)(OR)NR2, —OP(O)(NR2)2, —NRC(O)OR, —NRC(O)R, —NRC(O)NR2, —NRS(O)2R, —NP(O)R2, —NRP(O)(OR)2, —NRP(O)(OR)NR2, —NRP(O)(NR2)2, or —NRS(O)2R;
• z is 0, 1, 2, 3, or 4;
• Ring F is an optionally substituted fused ring selected from a 6-membered aryl, a 5-6 membered heteroaryl containing 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and a 5-7 membered saturated or partially unsaturated carbocyclyl or heterocyclyl with 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• X is an optionally substituted —(CH2)x—, wherein:
• x is 0, 1, 2, or 3;
• Y is an optionally substituted —(CH2)y—, wherein:
• y is 0, 1, 2, or 3;
• Ring M is an optionally substituted bivalent ring selected from phenylenyl, naphthylenyl, a 5-10 membered heteroarylenyl containing 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-11 membered saturated or partially unsaturated carbocyclylenyl or heterocyclylenyl with 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• Q is a bivalent moiety selected from —O—, —CR2—, —CF2—, —CFR—, —C(O)—, —OCR2—, and —C(S)—;
• and
• Ry1 and Ry2 are each independently hydrogen, RA, —CH2CO2R, or —CH2OCO2R.