Prophylactic or therapeutic drug for parkinson's disease

A method for preventing or treating Parkinson's disease, the method comprising administering a trisulfide compound, and a drug utilized in dopamine replacement therapy or a pharmaceutically acceptable salt thereof to a patient in need thereof, wherein the trisulfide compound is glutathione trisulfide or a pharmaceutically acceptable salt thereof, a compound represented by Formula (1):

• wherein X represents —OR1 or —NR2R3, R1 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R2 and R3 each independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, the alkyl group optionally having one or more substituents selected from the group consisting of an amino group and a carboxy group, a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof, pantethine trisulfide or a pharmaceutically acceptable salt thereof, or N,N′-diacetyl-L-cysteine trisulfide or a pharmaceutically acceptable salt thereof.

A kit for preventing or treating Parkinson's disease, the kit comprising:

• a formulation comprising a trisulfide compound;
• and a formulation comprising a drug utilized in dopamine replacement therapy, wherein the trisulfide compound is glutathione trisulfide or a pharmaceutically acceptable salt thereof, a compound represented by Formula (1):
• wherein X represents —OR1 or —NR2R3, R1 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R2 and R3 each independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, the alkyl group optionally having one or more substituents selected from the group consisting of an amino group and a carboxy group, a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof, or pantethine trisulfide or a pharmaceutically acceptable salt thereof, or N,N′-diacetyl-L-cysteine trisulfide or a pharmaceutically acceptable salt thereof.

A pharmaceutical composition for preventing or treating Parkinson's disease, the composition comprising a trisulfide compound, and a drug used for dopamine replacement therapy or a pharmaceutically acceptable salt thereof to a patient in need thereof, wherein the trisulfide compound is glutathione trisulfide or a pharmaceutically acceptable salt thereof, a compound represented by Formula (1):

• wherein X represents —OR1 or —NR2R3, R1 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R2 and R3 each independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, the alkyl group optionally having one or more substituents selected from the group consisting of an amino group and a carboxy group, a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof, pantethine trisulfide or a pharmaceutically acceptable salt thereof, or N,N′-diacetyl-L-cysteine trisulfide or a pharmaceutically acceptable salt thereof.