Naphthalenesulfonyl compounds, and preparation methods and applications
AssigneeFudan University
InventorsHuiru TANG, Pengcheng LI
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Abstract
The present disclosure provides naphthalenesulfonyl compounds, preparation methods and application thereof. Specifically disclosed is a compound of formula (I) or a salt thereof, which serves as a specific derivatization reagent capable of reacting with hydroxyl and amino groups. The compound features simple synthesis, high reactivity, and ready availability at low cost, and is capable of improving chromatographic separation behaviors of target compounds and enhancing the detection sensitivities of these compounds.
Claims24
A compound of formula (I) or a salt thereof:
- wherein R1 and R1′ are independently selected from C1-7 alkyl;
- R2 is selected from H, C1-7 alkyl, or benzyl;
- and
- X is selected from OH or halogen.
A preparation method for a compound of formula (I), comprising:
- subjecting a compound of formula (III) to a condensation reaction with a compound of formula (IV) in the presence of an activating agent and a base in a solvent to obtain the compound of formula (I):
- wherein, X is OH, R1 and R1′ are independently selected from C1-7 alkyl, and R2 is selected from H, C1-7 alkyl, or benzyl.
A preparation method for a compound of formula (I), comprising:
- subjecting a compound of formula (III) to a condensation reaction with a compound of formula (IV) in the presence of an activating agent and a base in a solvent to obtain a compound of formula (V):
- and
- subjecting the compound of formula (V) to an acylation reaction with a chlorinating agent to obtain the compound of formula (I):
- wherein, X is Cl, R1 and R1′ are independently selected from C1-7 alkyl, and R2 is selected from H, C1-7 alkyl, or benzyl.
An isotope-labeled compound of formula (II) or a salt thereof:
- wherein Y is
- R1 and R1′ are independently selected from C1-7 alkyl;
- R2 is selected from H, C1-7 alkyl, or benzyl;
- X is selected from OH or halogen;
- and
- at least one atom in Y is substituted by a heavier isotope thereof.
Dependencies are inferred from the claim text.