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US 2024/0285676 A1Published application
Bottlebrush polymers and methods thereof
AssigneeRegents of the University of Minnesota
InventorsJoseph Franklin Hassler, Adelyn Crabtree, Benjamin Hackel, Frank S. Bates, Timothy P. Lodge, Joseph M. Metzger
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Abstract
The present disclosure relates to bottlebrush polymers and methods thereof. Methods can include methods of stabilizing an interface, stabilizing a cell, or treating a disease, disorder, or condition using an effective amount of the bottlebrush polymer.
Claims20
A polymer comprising a structure of Formula I:
- wherein:
- each of Block A, Block B, and Block C of the polymer, independently, comprises a backbone polymer comprising one or more repeating units, wherein at least one of the one or more repeating units is covalently linked to a side chain;
- and
- each of y and z is, independently, 0 or 1;
- wherein:
- a first side chain of Block A is a hydrophilic side chain;
- a second side chain of Block B is a hydrophobic side chain;
- and
- a third side chain of Block C is a hydrophilic side chain that is different from the first side chain;
- and
- wherein the polymer is characterized by a molecular weight distribution (Ð) of less than about 1.5, 1.2, 1.15, or 1.1,
- wherein Block A comprises poly(ethylene oxide), and
- wherein Block B comprises poly(propylene oxide).
10 more elements
A method of preparing a monomer of Formula III:
- the method comprising:
- (i) forming a reaction mixture comprising an alkoxide of R7a OH and an epoxide of
- under conditions suitable to prepare a compound of Formula IIIA and a compound of Formula IIIB:
- wherein:
- each R7a is, independently, C3-12 alkyl;
- each R8 is, independently, hydrogen, C1-6 alkyl, aryl, heteroaryl, C1-6 alkyl, C1-6 alkyl-aryl, aryl-C1-6 alkyl, C1-6 alkyl-heteroaryl, or heteroaryl-C1-6 alkyl;
- R7′ does not include alkenyl;
- R7″ comprises alkenyl or alkynyl;
- each of R7′ and R7″ is a reacted form of R7a;
- and
- q is 5-200;
- (ii) forming a reaction mixture comprising a compound of Formula IIIA, a compound of Formula IB, and a hydrogenation catalyst under conditions suitable to prepare a compound of Formula IA and a compound of Formula IIIC:
- wherein R7″* comprises an unsaturated version of R7″;
- (iii) forming a reaction mixture comprising a compound of Formula IIA, a compound of Formula IIIC, and a compound of
- under conditions suitable to prepare a compound of Formula III;
- wherein:
- each R7 is, independently, independently, C3-12 alkyl.
14 more elements
Dependencies are inferred from the claim text.