Non-peptide targeted therapeutics and uses thereof

A compound of Formula (I), or a pharmaceutically acceptable salt thereof:

• wherein:
• (a) NP is a non-peptide ligand that binds to a gonadotropin-releasing hormone receptor (GnRHR) expressed in tumor cells;
• (b) a payload moiety (Q) comprising a chemotherapeutic;
• and
• (c) a linker (L) that covalently connects the non-peptide ligand NP and the payload moiety Q;
• wherein NP has a structure of Formula (X), or a pharmaceutically acceptable salt thereof:
• wherein:
• V is CH or N;
• and W is CH or N;
• T is absent, —CH2—, —CH(CH3)—, or —C(CH3)2—:
• X2 is absent, —O—, or —N(R7)—;
• and
• R7 is hydrogen or substituted or unsubstituted C1-C6alkyl:
• wherein upon administration to a mammal, the compound of Formula (I), or a pharmaceutically acceptable salt thereof, is targeted to tumor cells expressing the GnRHR.