Printed composition for biomedical uses
OwnerDaniele FORESTI, Armand KURUM +1inventors
InventorsDaniele FORESTI, Armand KURUM, Jennifer A. LEWIS
Life of this patent
Estimating the term…
Abstract
A printed composition for biomedical uses comprises a liquid droplet prior to crosslinking and a gelled particle after crosslinking, where the liquid droplet comprises a formulation including a hydrogel precursor and abiologic, and the gelled particle comprises a cross-linked hydrogel matrix with the biologic dispersed therein. The formulation has a viscosity in a range from about 100 mPa-s to about 500,000 mPa-s.
Claims23
A printed composition comprising:
- a liquid droplet prior to crosslinking and a gelled particle after crosslinking, the liquid droplet comprising a formulation including a hydrogel precursor and a biologic, and the gelled particle comprising a cross-linked hydrogel matrix with the biologic dispersed therein, wherein the formulation has a viscosity in a range from about 100 mPa·s to about 500,000 mPa·s.
(canceled)
(canceled)
A method of acoustophoretically printing a composition, the method comprising:
- arranging a nozzle within a first fluid, the nozzle having a nozzle opening;
- generating an acoustic field in the first fluid by an oscillating emitter;
- driving a formulation comprising a hydrogel precursor and a biologic out of the nozzle so as to form a pendant droplet comprising the formulation at the nozzle opening;
- detaching the pendant droplet by acoustic forces from the acoustic field, the formulation thereby being released in the first fluid as a liquid droplet;
- and
- crosslinking the liquid droplet to form a gelled particle comprising a crosslinked hydrogel matrix with the biologic dispersed therein.
(canceled)
A printed composition comprising:
- a gelled particle comprising a cross-linked hydrogel matrix with a biologic dispersed therein,
- wherein the gelled particle is obtained by crosslinking a liquid droplet comprising a formulation including a hydrogel precursor and the biologic, the formulation having a viscosity in a range from about 100 mPa·s to about 500,000 mPa·s.
Dependencies are inferred from the claim text.