Method for detecting amyloid-ß bound to brain-neuronalcell-derived exosome in blood, kit for detection of amyloid-ß bound to brain-neuronal-cell-derived exosome in blood, and method for evaluating accumulation level of amyloid-ß in brain

A kit for detection of amyloid-β bound to a brain-neuronal-cell-derived exosome in blood, the kit comprising:

• an amyloid-β-specific binding substance that specifically binds to amyloid-β, labeled with a nucleic acid fragment.

A kit for detection of amyloid-β bound to a brain-neuronal-cell-derived exosome in blood, comprising:

• a biomarker-specific binding substance on a surface of a brain-neuronal-cell-derived exosome, which specifically binds to a biomarker present on the surface of the exosome, labeled with a nucleic acid fragment;
• and
• an amyloid-β-specific binding substance that specifically binds to amyloid-β.

A method for evaluating an accumulation level of amyloid-β in a brain, the method comprising:

• a step of detecting amyloid-β bound to a brain-neuronal-cell-derived exosome in blood;
• and
• a step of evaluating an accumulation level of amyloid-β in a brain based on the detected amount of the amyloid-β.