Substituted acyl sulfonamides for treating cancer

A compound of general formula (I),

• wherein:
• R1 is a hydrogen atom;
• R2 is a hydrogen atom;
• R3 is selected from a hydrogen atom and a fluorine atom;
• R4 is a hydrogen atom;
• R5 is a hydrogen atom;
• R6 is selected from a phenyl group, a naphthyl group and a heteroaryl group,
• wherein said phenyl, naphthyl or heteroaryl group is each optionally substituted with one or more substituents independently selected from a halogen atom, a hydroxy group, a C1-C6-alkyl group, a C1-C6-hydroxyalkyl group, a C1-C6-haloalkyl group, a C1-C6-alkoxy group, a (C1-C3-alkyl)-O—(C1-C2-alkyl)- group, a (C1-C3-alkyl)-O—(C1-C2-alkyl)-O— group, a (C3-C8-cycloalkyl)-(C1-C2-alkyl)-O— group, a (C3-C8-halocycloalkyl)-(C1-C2-alkyl)-O— group, a (phenyl)-(C1-C2-alkyl)-O— group, a C1-C6-haloalkoxy group, a C2-C6-alkenyl group, a C3-C8-cycloalkyl group, a C3-C8-cycloalkoxy group, a C1-C6-thioalkyl group, a heterocycloalkyl group, a R7R8N— group, a (C1-C2-alkyl)-S(═O)2— group, a (phenyl)-S(═O)2— group, a (R7R8N)—S(═O)2— group, a (H3C)—(C═O)— group, a (R7R8N)—(C═O)— group, a (R7R8N)—(C═O)—O— group, a (R7R8N)—(C═O)— group, a R9OOC—(C1-C3-alkyl)- group, a R9OOC— group, a phenyl group, a (phenyl)-O— group and a heteroaryl group,
• wherein said heterocycloalkyl group is connected to the rest of the molecule via a carbon atom of said heterocycloalkyl group,
• wherein said phenyl, heteroaryl or heterocycloalkyl group is each optionally substituted with one or more substituents independently selected from a halogen atom, a C1-C3-alkyl group, a phenyl group and a R9OOC— group;
• R7 and R8 are each independently selected from a hydrogen atom, a C1-C6-alkyl group, a C3-C8-cycloalkyl group and a phenyl group,
• wherein said phenyl group is optionally substituted with one or more substituents independently selected from a halogen atom, a C1-C3-alkyl group, a C1-C3-haloalkyl group and a C1-C3-alkoxy group;
• or R7 and R8 together with the nitrogen atom to which they are attached form a 4- to 7-membered nitrogen-containing heterocycloalkyl group, wherein said heterocycloalkyl group optionally contains one, two or three further heteroatoms independently selected from nitrogen, oxygen and sulfur and is optionally substituted with one or more substituents independently selected from a halogen atom, a C1-C3-alkyl group, a C1-C3-haloalkyl group, a C1-C3-alkoxy group and a phenyl group;
• R9 is selected from a hydrogen atom, a C1-C3-alkyl group and a C3-C6-cycloalkyl group;
• Ra and Rb together with the nitrogen atom to which they are attached form a 4- membered nitrogen-containing heterocycloalkyl group which is optionally substituted one, two or three times, each substituent independently selected from a halogen atom, a C1-C2-alkyl group, a C1-C2-haloalkyl group, a C1-C2-alkoxy group, a C1-C3-hydroxyalkyl group and a phenyl group;
• or a tautomer, or an N-oxide, or a salt thereof, or a salt of a tautomer, or a salt of an N-oxide, or a mixture of same.