Multivalent influenza vaccines comprising recombinant hemagglutinin and neuraminidase and methods of using the same

An immunogenic composition comprising a plurality of recombinant influenza virus proteins, wherein the plurality of recombinant influenza virus proteins comprises:

• a first recombinant influenza virus hemagglutinin (HA), wherein the first recombinant influenza virus HA is an H1 HA;
• a second recombinant influenza virus HA, wherein the second recombinant influenza virus HA is an H3 HA;
• a third recombinant influenza virus HA, wherein the third recombinant influenza virus HA is from a B/Victoria lineage;
• a fourth recombinant influenza virus HA, wherein the fourth recombinant influenza virus HA is from a B/Yamagata lineage;
• a first recombinant influenza virus neuraminidase (NA), wherein the first recombinant influenza virus NA is an N1 NA;
• a second recombinant influenza virus NA, wherein the second recombinant influenza virus NA is an N2 NA;
• a third recombinant influenza virus NA, wherein the third recombinant influenza virus NA is from a B/Victoria lineage;
• and
• a fourth recombinant influenza virus NA, wherein the fourth recombinant influenza virus NA is from a B/Yamagata lineage.