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US 2024/0277803 A1Published application
Nme inhibitors and methods of using nme inhibitors
AssigneeMinerva Biotechnologies Corporation
InventorsCynthia Bamdad, Benoit Smagghe
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Abstract
The present application discloses inhibitors of NME family of proteins.
Claims20
A method of transforming a cancer cell to a more metastatic cancer stem cell comprising contacting the cancer cell with an NM23 protein that activates MUC1*.
A method of preventing cancer or cancer metastasis by vaccinating a person with an NME family protein or peptide fragment or fragments thereof.
A method of generating or selecting an antibody or antibody-like molecule that specifically binds to a bacterial NME family protein or peptide fragment thereof, comprising:
- (i) screening an antibody library or library of antibody fragments or epitopes with the bacterial NME family protein or peptide fragment;
- (ii) assaying for binding to the bacterial NME family protein or a peptide fragment thereof;
- and
- (iii) identifying the specifically bound antibody or antibody-like molecule.
1 more element
Dependencies are inferred from the claim text.