Compounds

A method of treating cancer, comprising administering to a patient in need thereof a compound of formula (I), or a pharmaceutically acceptable salt thereof:

• wherein either:
• (i)
• X0 = CRC,
• X1 = N,
• X2 = O;
• or
• (ii)
• X0 = CRC,
• X1 = O,
• X2 = N;
• or
• (iii)
• X0 = S,
• X1 = N,
• X2 = N;
• or
• (iv)
• X0 = N,
• X1 = N,
• X2 = O;
• or
• (v)
• X0 = O,
• X1 = N,
• X2 = N;
• where RC is H, CO2CH3 or C1;
• RN is H or methyl;
• X3 is CR3 or N;
• X4 is CR4 or N;
• R1 to R5 are independently selected from:
• (i) H;
• (ii) halo;
• (iii) cyano;
• (iv) C1-3 alkyl, optionally substituted by one or more fluoro groups;
• (v) (CH2)n0—C3-6 cycloalkyl, where n0=0 or 1;
• (vi) (CH2)n1—C1-3 alkoxy, where n1=0 or 1, optionally substituted by one or more fluoro groups;
• (vii) C1-3 alkylester;
• (vii) (CH2)n2-phenyl, where n2=0-2;
• and
• (viii) (CH2)n3-05 heteroaryl, where n3=0-1, optionally substituted by methyl;
• and
• RY is selected from:
• (i) (CH2)n4-phenyl, where n4=0-2, where phenyl is optionally substituted by:
• (a) C1-4 alkyl, optionally substituted by one or more fluoro groups;
• (b) C1-4 alkoxy, optionally substituted by phenyl, or one or more fluoro groups;
• (c) halo;
• (d) cyano, nitro or amido;
• (e) phenyl;
• or
• (f) —(CH2)n5—, where n5 is 3 or 4;
• (ii) pyridyl;
• (iii) C3-4 alkyl;
• (iv) (CH2)n6—C3-6 cycloalkyl, where n6=0-2;
• (v) C6 heterocyclyl, optionally substituted by C1-4 alkylester;
• and
• (vi) NHRYN, where RYN is selected from phenyl or cyclohexyl.