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AssigneeJiangsu Kanionreal Biomedical Technology Co., Ltd
InventorsWei XIAO, Deshan LI, Tianyan LIU, Zhihang LIU, Zhenzhong WANG, Shan JIANG, Xiaolian HE, Xuehong DONG, Yanqiu WANG
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A recombinant Newcastle disease virus and a preparation method therefor, a recombinant plasmid, and use of the recombinant Newcastle disease virus or the recombinant plasmid. The recombinant Newcastle disease virus is obtained by replacing an F protein of a Newcastle disease virus lasota with an F protein encoded by a DNA as set forth in SEQ ID NO: 1 at positions 7274-8935 from a 5′-terminus. The recombinant Newcastle disease virus is safe and capable of effectively inhibiting tumour cells and promoting tumour cell apoptosis.
1-12. (canceled)
A recombinant Newcastle disease virus, obtained by replacing an F protein of a Newcastle disease virus lasota with an F protein of a Newcastle disease virus mesogenic strain.
A recombinant plasmid, obtained by replacing an F gene in a pBrlasota plasmid, wherein the F gene of the recombinant plasmid is as set forth in SEQ ID NO:
A preparation method for a recombinant Newcastle disease virus, comprising transfecting the recombinant plasmid according to claim 5 to cells or cell line for culturing to obtain the recombinant Newcastle disease virus.
Dependencies are inferred from the claim text.