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US 2024/0269256 A1Published application
Compositions and methods for enhanced antigen binding proteins
AssigneeHDT Bio Corp.
InventorsJesse Hong-Sae Erasmus, Jacob Freeman Archer
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Abstract
The disclosure provides nanoparticle and compound compositions and methods of making and using the same to a nucleic acid encoding a protein, antibody, or functional fragment thereof for administration to a subject. Various nanoparticle carriers are described. In some instances, the nanoparticle component may include a hydrophobic core having an inorganic particle, and optionally a membrane having a cationic lipid.
Claims35
A composition, wherein the composition comprises:
- a nanoparticle carrier;
- and
- a nucleic acid, wherein the nucleic acid comprises:
- (i) a region encoding for an RNA-dependent RNA polymerase;
- (ii) a region encoding for a non-enveloped virus structural protein;
- and
- (iii) a region encoding for a virus protease, wherein the virus structural protein is a substrate for the virus protease.
4 more elements
Dependencies are inferred from the claim text.