Isolation and use of human lymphoid organ-derived suppressive stromal cells
AssigneesThe General Hospital Corporation d/b/a Massachusetts General Hospital, Dana-Farber Cancer Institute, Inc.
InventorsAnne Fletcher, Shannon J. Turley, Biju Parekkadan
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Abstract
A method for suppressing an immune response is provided. The method involves administration of isolated lymphoid tissue-derived suppressive stromal cells (LSSC) to a subject in need of such treatment in an amount effective to suppress the immune response in the subject. The invention also involves a method to isolate LSSC by digesting lymphoid tissue fragments using a combination of an enzyme mix and agitation and then collecting the LSSC. Pharmaceutical preparations comprising LSSC are also provided.
Claims35
A method for suppressing an immune response comprising:
- administering to a subject in need of such treatment isolated lymphoid tissue-derived suppressive stromal cells (LSSC) in an amount effective to suppress the immune response in the subject.
A method of isolating lymphoid tissue-derived suppressive stromal cells (LSSC) comprising digesting lymphoid tissue fragments using a combination of an enzyme mix and agitation, and then collecting the LSSC.
A pharmaceutical preparation comprising a composition of isolated lymphoid tissue-derived suppressive stromal cells (LSSC).
Dependencies are inferred from the claim text.