System and method for predicting susceptibility of genus klebsiella to amikacin

A method for predicting susceptibility of genus klebsiella to amikacin, comprising:

• step 1, calculating a k value according to the following formula I:
• k
• =
• -
• 1
• .
• 4
• ⁢
• 4
• ⁢
• 6
• +
• 0
• .
• 5
• ⁢
• 0
• ⁢
• 1
• ×
• (
• C
• ⁢
• 1
• -
• 0.018
• 0.164
• )
• -
• 0
• .
• 1
• ⁢
• 0
• ⁢
• 8
• ×
• (
• C
• ⁢
• 2
• -
• 1.07
• 0
• .
• 0
• ⁢
• 7
• ⁢
• 5
• )
• +
• 1
• .
• 0
• ⁢
• 9
• ⁢
• 3
• ×
• (
• C
• ⁢
• 3
• -
• 0.025
• 0
• .
• 2
• ⁢
• 2
• ⁢
• 6
• )
• -
• 1.031
• ×
• (
• C
• ⁢
• 4
• -
• 0
• .
• 9
• ⁢
• 0
• ⁢
• 6
• 0.413
• )
• +
• 2
• .
• 7
• ⁢
• 1
• ⁢
• 0
• ×
• (
• C
• ⁢
• 5
• -
• 0.521
• 1
• .
• 0
• ⁢
• 8
• ⁢
• 2
• )
• ;
• and
• (
• formula
• ⁢
• I
• )
• step 2, calculating an Exp(−k) power value with an Euler's constant e as a base and a −k value as an exponential;
• wherein in the formula I, C1 represents a copy number of an arr-2 gene in klebsiella strains;
• C2 represents a copy number of an acrB gene in the klebsiella strains;
• C3 represents a copy number of an armA gene in the klebsiella strains;
• C4 represents a copy number of an oqxB gene in the klebsiella strains;
• C5 represents a copy number of a rmtB gene in the klebsiella strains;
• and
• wherein a decision threshold comprises:
• the Exp(−k) power value less than 1 corresponding to the genus klebsiella resistant to the amikacin, and the Exp(−k) power value greater than or equal to 1 corresponding to the genus klebsiella susceptible to the amikacin;
• and the method further comprises:
• administering the amikacin to a patient in a medication treatment based on the decision threshold.