Selenium Maleimide Compounds And Uses Thereof

A compound with the structure of Formula (I):

• wherein A is a naturally occurring isotope of selenium (Se);
• R1 is selected from H, unsubstituted or substituted C1-C20 alkyl, unsubstituted or substituted C3-C14 cycloalkyl, unsubstituted or substituted aryl, and an electron withdrawing group;
• R2 is selected from H, unsubstituted or substituted C1-C20 alkyl, unsubstituted or substituted C1-C20 alkenyl, unsubstituted or substituted C3-C14 cycloalkyl, unsubstituted or substituted aryl, A-R1, and an electron withdrawing group;
• such that R1 and R2, together with the atoms to which they are bonded, form a 4 to 6 membered monocyclic, saturated or unsaturated ring, which may be substituted or unsubstituted;
• L is C1-C20 alkyl, unsubstituted or substituted with one or more substituents and/or optionally interrupted with one or more heteroatom(s) or heteroatom(s) containing group(s) independently selected from O, S, NR3, C(O), C(S), C(O)NHR3, and NHR3C(O);
• wherein R3 is H, or unsubstituted or substituted C1-C20 alkyl;
• X is a reactive functional group selected from halo, OH, OTs, OMs, C(O)H, C(O)OR3, C(O)NR4R5, O—C(O)—OR3, OC(O)—NR4, C(O)ONR5R6, C(O)R7, C(O)SR3, and NR8R9;
• R3 is selected from H, unsubstituted or substituted C1-C20 alkyl, and unsubstituted or substituted aryl;
• R4 is selected from H, unsubstituted or substituted C1-C20 alkyl, and unsubstituted or substituted aryl;
• R5 and R6 are independently selected from H, unsubstituted or substituted C1-C20 alkyl, and unsubstituted or substituted aryl;
• R7 is selected from H, unsubstituted or substituted C1-C20 alkyl, and halo,
• R8 and R9 are independently selected from H, unsubstituted or substituted C1-C20 alkyl, C(O)C1-C6 alkyl, unsubstituted or substituted aryl, or
• R8 and R9, together with the nitrogen atom to which they are bonded, form a 4 to 12 membered monocyclic or bicyclic saturated or unsaturated ring unsubstituted or substituted with one or more ═O, ═S, halo, and C1-C6 alkyl;
• and
• one or more hydrogens are replaced with deuterium (D);
• or a salt and/or solvate thereof, with a proviso such that when X is C(O)OR3 and R3 is H, L is not C2 alkyl.