Microneedle-Mediated Wearable Dermal Patch and Methods of Use for Collection of Biological Fluid

Abstract

The present invention provides dermal patches and methods of use for collecting biological fluid in proximity to a lymph node for ex vivo or in situ detection of a trigger analyte. In one embodiment, the invention provides a method for collecting a biological fluid sample, the method comprising: a) applying a dermal patch comprising a microneedle array to a skin location in proximity to at least one lymph node in a subject or patient; b) contacting the microneedle array intradermally to access a biological fluid; c) allowing the microneedle array to take up a biological fluid sample; d) collecting the biological fluid sample into a sampling chamber housed within the dermal patch. Additional steps can include activating the microneedle array by applying pressure or electric current.

Dependencies are inferred from the claim text.