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US 2024/0257976 A1Published application
Gene mutations associated with tandem duplicator phenotype
AssigneeThe Jackson Laboratory
InventorsEdison T. Liu, Francesca Menghi
Life of this patent
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Abstract
Provided herein, in some embodiments, are methods for classifying the tandem duplicator phenotype of a tumor.
Claims10
-20. (canceled)
A method, comprising:
- (a) identifying a subject as a candidate for a therapy that targets a tumor comprising tandem duplications in PTEN, RB1, NF1, ERRB2, MYC1, ESR1, MDM2 and/or lncRNA MALAT1 based on a tandem duplicator phenotype (TDP) subtype of the tumor;
- and
- (b) administering to the subject a therapy that comprises a platinum-based agent and/or an alkylating agent.
Dependencies are inferred from the claim text.