Biomarkers for mitochondrial and metabolic disorders
AssigneeBoard of Trustees of the University of Arkansas
InventorsShilpa Iyer, Raj R. Rao, Shilpi Agrawal
Life of this patent
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Abstract
Embodiments of the present disclosure pertain to methods of assessing one or more mitochondrial or metabolic disorders in a subject by receiving one or more measured biomarker levels of the subject and correlating differentially expressed levels of the one or more measured biomarkers to one or more mitochondrial or metabolic disorders in the subject. Such methods may also include a step of making a treatment decision based on the assessment. Additional embodiments of the present disclosure pertain to a computing device for assessing one or more mitochondrial or metabolic disorders in a subject in accordance with the methods of the present disclosure.
Claims23
A method of assessing one or more mitochondrial or metabolic disorders in a subject, said method comprising:
- receiving one or more measured biomarker levels of the subject, wherein the one or more measured biomarker levels is selected from the group consisting of putrescine, N-acetyl putrescine, N-acetyl ornithine, N-acetyl spermidine, N-acetyl arginine, gamma amino butyric acid (GABA), opthalmic acid, S-adenosyl methionine, creatine, or combinations thereof;
- and
- correlating differentially expressed levels of the one or more measured biomarkers to the one or more mitochondrial or metabolic disorders in the subject.
A computing device for assessing one or more mitochondrial or metabolic disorders in a subject, wherein the computing device comprises one or more computer readable storage mediums having a program code embodied therewith, wherein the program code comprises programming instructions for:
- receiving one or more measured biomarker levels of the subject, wherein the one or more measured biomarker levels is selected from the group consisting of putrescine, N-acetyl putrescine, N-acetyl ornithine, N-acetyl spermidine, N-acetyl arginine, gamma amino butyric acid (GABA), opthalmic acid, S-adenosyl methionine, creatine, or combinations thereof;
- and
- correlating differentially expressed levels of the one or more measured biomarkers to the one or more mitochondrial or metabolic disorders in the subject.
Dependencies are inferred from the claim text.