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AssigneeThe Regents of the University of California
InventorsEdward C. Kuan, Michelle Khine, Andrej Luptak, Arash Abiri, Julia A. Zakashansky, Xinlei Chen
Estimating the term…
A portable device for detection of cerebrospinal fluid (CSF) in a sample. The device may comprise a substrate and a sensor disposed on the substrate, the sensor comprising a sensing area. The sensor further comprises an aptamer solution comprising an aptamer sequence functionalized by a redox agent to be sensitive to the CSF biomarker and functionalized to attach to the sensor. The sensor may be configured to be sensitive to a CSF biomarker. The device may further comprise an electrochemical detection component operatively coupled to the sensor. When a sample containing an amount of the CSF biomarker is disposed on the sensing area of the sensor, the electrode may generate a detection signal to be transmitted to the electrochemical detection component. The electrochemical detection component may transmit the detection signal to the computing device.
A portable device (100) for detection of cerebrospinal fluid (CSF) in a sample, the device (100) comprising:
A method for detecting cerebrospinal fluid (CSF) in a sample, the method comprising:
An aptamer comprising a first end and a second end, wherein the first end is functionalized by a redox agent to be sensitive to one or more molecules found in cerebrospinal fluid (CSF), and wherein the second end is functionalized to attach to a surface of an electrode, wherein the aptamer is according to any one of SEQ ID NO:
Dependencies are inferred from the claim text.