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US 2024/0254455 A1Published application
Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins
AssigneeThe General Hospital Corporation
InventorsJae Keith Joung, Eric M. Mendenhall, Bradley E. Bernstein, Deepak Reyon
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Abstract
Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array (TALE) or zinc finger array, and a catalytic domain comprising a sequence that catalyzes histone demethylation, and methods of use thereof.
Claims16
1-23. (canceled)
A method of reducing methylation of histones associated with a selected DNA sequence in a mammalian cell, the method comprising contacting the cell with a fusion protein comprising an engineered transcription activator-like (TAL) effector repeat array that binds specifically to an enhancer, and
- a catalytic domain comprising a sequence that catalyzes histone demethylation.
Dependencies are inferred from the claim text.