ANTI-HUMAN INTERFERON a RECEPTOR 1 MONOCLONAL ANTIBODY AND APPLICATION THEREOF
AssigneeQyuns Therapeutics Co., Ltd.
InventorsJiwan QIU, Yong KONG, Wei CHEN, Huaiyao QIAO, Zhihua QIU, Yiliang WU, Tao CHEN, Meijuan WU
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Abstract
Provided are an anti-human interferon α receptor 1 (IFNAR1) monoclonal antibody and an application thereof. Compared with anti-human IFNAR1 monoclonal antibody Anifrolumab, the anti-human (IFNAR1) monoclonal antibody of the present application has a similar binding affinity to human IFNAR1, and the neutralizing activity thereof at the cellular level is comparable to that of Anifrolumab. In addition, the present application is expected to be used for the prevention and treatment of related diseases.
Claims10
An isolated anti-human interferon alpha receptor 1 monoclonal antibody, comprising three heavy chain complementarity determining regions (CDR-H1, CDR-H2 and CDR-H3) and three light chain complementarity determining regions (CDR-L1, CDR-L2 and CDR-L3), wherein:
- (a) the amino acid sequence of CDR-H1 is shown as SEQ ID NO:
- 1;
- (b) the amino acid sequence of CDR-H2 is shown as SEQ ID NO:
- 2;
- (c) the amino acid sequence of CDR-H3 is shown as SEQ ID NO:
- 3;
- (d) the amino acid sequence of CDR-L1 is shown as SEQ ID NO:
- 4;
- (e) the amino acid sequence of CDR-L2 is shown as SEQ ID NO:
- 5;
- and
- (f) the amino acid sequence of CDR-L3 is shown as SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.