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US 2024/0254205 A1Published application
Anti-influenza neuraminidase monoclonal antibodies and uses thereof
AssigneeUniversity of Rochester
InventorsJames J. Kobie, Luis Martinez-Sobrido, Michael Piepenbrink, Aitor Nogales
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Abstract
The present invention relates to broadly neutralizing anti-influenza monoclonal antibodies or antigen-binding fragments thereof. The present invention further relates to therapeutic uses of the isolated antibody or the antigen-binding fragment thereof.
Claims18
An isolated antibody or antigen-binding fragment thereof that specifically binds to a neuraminidase of influenza virus, comprising:
- (i) a heavy chain variable region that comprises HCDR1, HCDR2, and HCDR3 comprising the respective sequences of a HCDR set selected from the group consisting of SEQ ID NOs:
- 11-13, SEQ ID NOs:
- 35-37, and SEQ ID NOs:
- 43-45, and
- (ii) a light chain variable region that comprises LCDR1, LCDR2, and LCDR3 comprising the respective sequences of a LCDR set selected from the group consisting of SEQ ID NOs:
- 14-16, SEQ ID NOs:
- 38-40, and SEQ ID NOs:
- 46-48.
5 more elements
Dependencies are inferred from the claim text.