Monoclonal antibody 2g1 for broad-spectrum neutralization of ebola viruses and application thereof
AssigneeAcademy of Military Medical Science, PLA
InventorsWei Chen, Changming Yu, Pengfei Fan, Xiangyang Chi, Guanying Zhang, Jianmin Li, Lihua Hou, Junjie Xu, Ting Fang, Shipo Wu, Yi Chen, Zhengshan Chen, Yujiao Liu, Meirong Wang
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Abstract
Disclosed is a monoclonal antibody 2G1 against an Ebola glycoprotein GP2 subunit. The monoclonal antibody has binding activity to EBOV GP, BDBV GP, SUDV GP, and RESTV GP, and can play a neutralizing role.
Claims10
An isolated monoclonal antibody that specifically binds to Ebola virus glycoprotein GP2 subunit, wherein the CDR1, CDR2 and CDR3 of light chain variable domain of the said antibody has the amino acid sequence as 27-32 of SEQ ID NO. 1, 50-52 of SEQ ID NO. 1 and 89-96 of SEQ ID NO. 1 respectively, the CDR1, CDR2 and CDR3 of heavy chain variable domain of the said antibody has the amino acid sequence as 26-33 of SEQ ID NO. 5, 51-58 of SEQ ID NO. 5 and 97-113 of SEQ ID NO. 5.
Dependencies are inferred from the claim text.