Rabies viral glycoprotein compositions and methods of use

Abstract

Disclosed are peptides comprising a first portion, a second portion and a third portion, wherein at least the second portion is a portion of a RVG peptide, and wherein at least one of the first or third portions is a nAChR subtype selective peptide In some aspects, the nAChR subtype selective peptide can be from an α-neurotoxin. Disclosed are peptides comprising a first portion, a second portion and a third portion, wherein the first portion is a nicotinic acetylcholine receptor (nAChR) subtype selective portion of an α-neurotoxin, wherein the second portion is a portion of a rabies viral glycoprotein (RVG) peptide, and wherein the third portion is a nicotinic acetylcholine receptor (nAChR) subtype selective portion of an α-neurotoxin. In some aspects, the RVG peptide is a cell penetrating portion. Disclosed are methods of using these peptides.

Dependencies are inferred from the claim text.