SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS

A compound of formula I:

• or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, wherein:
• A is a 5- or 6-membered aromatic ring comprising 0-3 heteroatoms of N, S or O;
• each W is independently —(CH2)— or —C(O)—;
• L is a bond, CH2, NR12, O, or S;
• S/D is a single bond or double bond, and when S/D is a double bond, R5 and R7 are absent;
• m is 0;
• n is 0, 1, 2, 3 or 4, wherein when n is 2, 3, or 4, each R2 is different or identical;
• p is 1;
• R1, R4, R5, R6 and R7 are each independently H, halogen, heteroalkyl, alkyl, alkenyl, cycloalkyl, aryl, saturated or unsaturated heterocyclyl, heteroaryl, alkynyl, —CN, —NR13R14, —OR13, —COR13, —CO2R13, —CONR13R14, —C(═NR13)NR14R15, —NR13COR14, —NR13CONR14R15, —NR13CO2R14, —SO2R13, —NR13SO2NR14R15, or —NR13SO2R14, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heteroaryl, aryl, and saturated or unsaturated heterocyclyl are optionally substituted with at least one substituent R16, wherein (R4 and R5) or (R4 and R6), or (R6 and R7), together with the atom(s) to which they are attached, form a ring selected from the group consisting of cycloalkyl, saturated or unsaturated heterocyclyl, aryl, and heteroaryl, each optionally substituted with at least one substituent R16;
• R2 is halogen, alkyl, —S-alkyl, —CN, —NR13R14, —OR13, —COR13, —CO2R13, —CONR13R14, —C(═NR13)NR14R15, —NR13COR14, —NR13CONR14R15, —NR13CO2R14, —SO2R13, —NR13SO2NR14R15, or —NR13SO2R14;
• R12 is H or lower alkyl;
• R13, R14 and R15 are each independently H, heteroalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, saturated or unsaturated heterocyclyl, aryl, or heteroaryl;
• wherein (R13 and R14), and/or (R14 and R15) together with the atom(s) to which they are attached, independently forms a ring selected from the group consisting of cycloalkyl, saturated or unsaturated heterocyclyl, aryl, and heteroaryl, each optionally substituted with at least one substituent R16;
• R16 is halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, oxo, —CN, —OR′, —NR′R″, —COR′, —CO2R′, —CONR′R″, —C(═NR′)NR″R′″, —NR′COR″,NR′CONR′R″, —NR′CO2R″, —SO2R′, —SO2aryl, —NR′SO2NR″R′″, or —NR′SO2R″, wherein R′, R″, and R′″ are independently hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, wherein (R′ and R″) and/or (R″ and R′″) together with the atom(s) to which they are attached, independently forms a ring selected from the group consisting of cycloalkyl, saturated or unsaturated heterocyclyl, aryl, and heteroaryl.