New Pyridine-Sulfonamide Derivatives as Sigma Ligands

A compound of the formula:

• or a salt thereof, a co-crystal thereof, a prodrug thereof, or a solvate thereof,
• wherein:
• A is a moiety or the formula:
• B is —NR1R1′;
• a branched or unbranched C1-6 alkyl radical;
• a branched or unbranched C1-6 haloalkyl radical;
• an heterocycloalkyl radical containing at least an O as heteroatom;
• or an heteroaryl radical containing at least one N as heteroatom optionally substituted with a C1-6 haloalkyl radical;
• one of W1 or W2 is —N— and the other is —CH—;
• each of R1 and R1′ is independently H, a branched or unbranched C1-6 alkyl radical or a moiety of the formula —C(O)R where R represents a C1-6 alkyl radical, with the proviso that at least one of R1 and R1′ is not H;
• or
• alternatively R1 and R1′ together with the nitrogen atom to which they are attached to form a 5- to 12-membered N-containing heterocyclic ring that (i) may further contain one or more additional heteroatoms selected from the group consisting of N, O or S, and (ii) is optionally substituted by one or more Ra radicals;
• each of Ra is independently H;
• a branched or unbranched C1-6 alkyl radical;
• halide;
• —CN;
• a C1-6 haloalkyl radical;
• —OH;
• a carbonyl group;
• or a C1-6 alkoxy radical;
• R2 is H or a branched or unbranched C1-6 alkyl radical;
• R3 is a branched or unbranched C3-10 alkyl radical;
• an alkylaryl radical;
• or an alkylheteroaryl radical;
• wherein the aryl and the heteroaryl groups is optionally substituted by one or more R3′ radicals;
• R3′ is a branched or unbranched C1-6 alkyl radical, halide, —CN, a C1-6 haloalkyl radical, —OH, or a C1-6 alkoxy radical;
• R4 is CH(NR2R3) or NR3;
• each of R5, R5′, R5″, and R5′″ is independently H;
• a branched or unbranched C1-6 alkyl radical;
• a C1-6 alkoxy radical;
• halide;
• C1-6 haloalkyl group;
• —OH, or —CN;
• each of R6 and R6′ is independently H;
• a branched or unbranched C1-6 alkyl radical;
• a C1-6 alkoxy radical;
• a halogen atom;
• a C1-6 haloalkyl group;
• —OH, or —CN;
• n is 0, 1 or 2;
• m is 0, 1 or 2;
• p is 0, 1 or 2;
• q is 0, 1 or 2;
• r is 0, 1 or 2;
• with the proviso that when R3 is a benzyl group, then R3′ is not an a C1-6 alkoxy radical.