Novel pyrimidine derivative, and composition for preventing or treating neurodegenerative diseases and cancer, comprising same

A compound represented by the following Chemical Formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof:

• wherein,
• R1 is each independently selected from the group consisting of a hydrogen, a halogen, a hydroxy, a cyano, an amino, an amide, nitro, a C1-C6 alkyl, C1-C6 alkoxy, and a halo C1-C6 alkoxy;
• R2 is a substituted or unsubstituted pyrazole,
• wherein the substituted pyrazole has as a substituent thereon at least one radical selected from the group consisting of a halogen, a hydroxy, a cyano, an amino, an amide, a nitro, a C1-C6 alkylsulfonyl, an acetyl, a methyloxycarbonyl, a substituted or unsubstituted C1-C6 alkyl, a substituted or unsubstituted benzyl, a substituted or unsubstituted C3-C12 cycloalkyl, a substituted or unsubstituted C3-C12 heterocycloalkyl, a substituted or unsubstituted C4-C12 aryl, and a substituted or unsubstituted C4-C12 hetaroaryl,
• wherein the substituted alkyl, the substituted benzyl, the substituted C3-C12 cycloalkyl, the substituted C4-C12 aryl, and the substituted C4-C12 hetaroaryl have each as a substituent thereon at least one radical selected from the group consisting of a halogen, a hydroxy, a cyano, an amino, an amide, a nitro, a C1-C6 alkyl, a C1-C6 alkoxy, a C3-C12 heterocycloalkyl, a C4-C12 an aryl-C1-C6 alkoxy, and a —C(═O)O-alkyl(C1-C6);
• R3 is a halogen or a halo C1-C6 alkyl;
• R4 is represented by any one of B-1 to B-29, below,
• wherein,
• R6 is selected from the group consisting of a hydrogen, a halogen, a hydroxy, a C1-C6 alkyl, a C1-C6 hydroxyalkyl, a C1-C6 alkylsulfonate, and a C1-C6 alkylamino;
• R7 is each independently selected from the group consisting of a hydrogen, a halogen, a halo C1-C6 alkyl, and a C1-C6 alkyl;
• R8 is each independently selected from the group consisting of a hydrogen, a halogen, an amino, a hydroxy, a cyano, a C1-C6 dialkylamino, an aminosulfonyl, a C1-C6 alkylsulfonamino, a C1-C6 alkyl, a halo C1-C6 alkyl, a halo C1-C6 alkyloxy, and a C1-C6 alkoxy;
• R9 is selected from the group consisting of a hydrogen, a halogen, a hydroxy, a hydroxy C1-C6 alkyl, a C1-C6 alkylsulfonyl, a C1-C6 alkylacetyl, a C1-C6 alkyloxycarbonyl, a C1-C6 alkylamino, a C1-C6 alkoxy, a morpholine, a piperidine, a pyrrolidine, an oxetanyl, a C1-C6 alkyl-substituted piperidine, and an acetate;
• R10 is selected from the group consisting of a hydrogen, a C1-C6 alkyl, a phenyl, an oxetanyl, and an acetate;
• R11 is a hydrogen or bonds to R10 to form a saturated or unsaturated C5-C6 heterocycloalkyl;
• R12 is a hydrogen or a C1-C6 alkyl;
• R13 is a hydrogen, a C1-C6 alkylcarbonyl, or a C1-C6 alkylacetyl;
• R14 is a hydrogen, a C1-C6 alkyl, a hydroxy C1-C6 alkyl, a C1-C6 alkoxy C1-C6 alkyl, a C1-C6 alkyloxycarbonyl C1-C6 alkyl, or a methylsulfonyl C1-C6 alkyl;
• Ak is a C1-C6 alkyl;
• k is each independently 0, 1, or 2 (with a provision that all k's are non-zero simultaneously);
• l is 1 or 2;
• m is 0, 1, 2, 3, or 4;
• n is 0 or 1,
• W is each independently CH or N;
• Z is O or SO2;
• X is C, CH, or N;
• and
• Y is selected from the group consisting of 0 and S.