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US 2024/0254101 A1Published application
Gpr52 modulator compounds
AssigneeHeptares Therapeutics Limited
InventorsSarah Joanne BUCKNELL, Stephen Paul WATSON, Michael Alistair O'BRIEN
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Abstract
The disclosures herein relate to novel compounds of Formula (1); and salts thereof, wherein X, Y, R1, R2, R3 and R4 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with GPR52 receptors.
Claims24
-25. (canceled)
A compound of Formula (1):
- or a salt thereof, wherein;
- X is N or CR5;
- Y is N or CR6;
- R1 is H, C1-6 alkyl optionally substituted with OH or 1 to 6 fluorine atoms, C3-6 cycloalkyl optionally substituted with OH or 1 to 6 fluorine atoms, wherein when the C1-6 alkyl or C3-6 cycloalkyl group is not substituted with OH, one atom of the C1-6 alkyl or C3-6 cycloalkyl group may be optionally replaced by an O atom which is not directly attached to the N or attached to a carbon atom which is directly attached to the N;
- or R1 is joined to R2 to form a 4, 5, 6 or 7-membered ring which is optionally substituted with OH or 1 to 6 fluorine atoms;
- R2 is H or C1-3 alkyl optionally substituted with OH or 1 to 6 fluorine atoms;
- or R2 is joined to R1 to form a 4, 5, 6 or 7-membered ring which is optionally substituted with OH or 1 to 6 fluorine atoms;
- R4, R5 and R6 are independently selected from H, CN, halo, C1-6 alkyl optionally substituted with OH or 1 to 6 fluorine atoms, C3-6 cycloalkyl optionally substituted with OH or 1 to 6 fluorine atoms and C1-6 alkoxy optionally substituted with 1 to 6 fluorine atoms, wherein when the C1-6 alkyl or C3-6 cycloalkyl group is not substituted with OH, one atom of the C1-6 alkyl or C3-6 cycloalkyl group may be optionally replaced by O;
- R3 is a group of the formula:
- L is CH2 or CHOH;
- the group:
- R8, R9 and R10 are independently selected from H, CN, halo, C1-6 alkyl optionally substituted with 1 to 6 fluorine atoms and C1-6 alkoxy optionally substituted with 1 to 6 fluorine atoms, wherein one atom of the C1-6 alkyl group may be optionally replaced by a heteroatom selected from O, N, S and oxidised forms thereof.
9 more elements
Dependencies are inferred from the claim text.