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US 2024/0254091 A1Published application
Toll like receptor modulator compounds
AssigneeGilead Sciences, Inc.
InventorsGregory Chin, Richard L. Mackman, Michael R. Mish, Jeff Zablocki
Life of this patent
Estimating the term…
Abstract
This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them.
Claims16
A compound of Formula I
- or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is —H, C1-4 alkyl, or C1-4 haloalkyl;
- R2 is C1-6 alkyl or C1-6 haloalkyl;
- Q is CR4;
- R3 and R4 are taken together to form:
- each R6 is optionally present and is independently halogen —OH, —NH2, —CN, C1-4 alkyl optionally substituted with 1 phenyl optionally substituted with 1 to 3 RZ, C1-4 haloalkyl, C1-4 alkoxy, —S(O)2C1-4 alkyl, 5 to 6 membered heterocyclyl having 1 to 3 heteroatoms selected from oxygen, nitrogen, and sulfur optionally substituted with 1 to 3 RZ, phenyl optionally substituted with 1 to 3 RZ, or 5 to 6 membered heteroaryl having 1 to 3 heteroatoms selected from oxygen, nitrogen, and sulfur optionally substituted with 1 to 3 RZ;
- and
- each RZ is independently —NH2, C1-4 alkyl, halogen, —CN, —OC1-4 alkyl, C1-4 haloalkyl, or —C(O)NH2;
- with the proviso that Formula I is not
7 more elements
(canceled)
-11. (canceled)
-19. (canceled)
-41. (canceled)
-50. (canceled)
Dependencies are inferred from the claim text.