Chelators for radiometals and methods of making and using same
AssigneeThe University of British Columbia
InventorsLuke WHARTON, Chris ORVIG
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Abstract
A chelator having the general structure (I) wherein each R1 is independently OH, NH or SH, and X is O, S, or NR3, wherein R3 is H or CH2C(═O)R1. Methods of making and using the chelator, metal chelates, and biological constructs for delivering targeted radiation therapy using the chelator are provided. (I).
Claims31
A chelator having the structure (I), wherein each R1 is independently OH, NH or SH, and X is O, S, or NR3, wherein R3 is H or CH2C(═O)R1:
A chelator having the structure (III) wherein each R1 is independently OH, NH or SH or a functional group;
- each R2 is independently H or a functional group;
- each R4 is independently H or a functional group, or both R4 together form a cyclohexyl moiety;
- each R5 is independently H or a functional group, or both R5 together form a cyclohexyl moiety;
- and X is O, S, or NR3, wherein one or more of the R1, R2, R4 or R5 groups is a functional group that allows coupling of the chelator to a biological targeting moiety, and wherein R3 is H or CH2C(═O)R1:
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Dependencies are inferred from the claim text.