Catalytic tryptamine processes and precursors

A process for the preparation of compounds of Formula (III):

• comprising contacting a compound of Formula (I):
• with a compound of Formula (II):
• in the presence of a catalyst,
• wherein,
• R1 is hydrogen, (C1-C20)-alkyl, (C2-C20)-alkenyl, (C2-C20)-alkynyl, (C3-C20)-cycloalkyl, (C6-C20)-aryl, (C5-C20)-heteroaryl, —C(═O)—(C1-C20)-alkyl, —(C═O)—O—(C1-C20)-alkyl, ORc, or NRc2, each of which are optionally substituted with halogen, OH, optionally substituted phenyl or (C1-C6)-alkyl, and wherein Rc is hydrogen, (C1-C20)-alkyl, (C2-C20)-alkenyl, (C2-C20)-alkynyl, (C3-C20)-cycloalkyl, or (C6-C20)-aryl, and one or more of the carbon atoms in the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or acyl groups of R1 is optionally replaced with a heteroatom selected from the group consisting of O, S, N, P and Si, which, where possible, is optionally substituted with one or more groups selected from halo, OH, optionally substituted phenyl or (C1-C6)-alkyl;
• R2 to R10 represent hydrogen, deuterium, (C1-C20)-alkyl, (C2-C20)-alkenyl, (C2-C20)-alkynyl, (C3-C20)-cycloalkyl, (C6-C20)-aryl, (C5-C20)-heteroaryl, —C(═O)—(C1-C20)-alkyl, or two adjacent or geminal groups are bonded together to form an optionally substituted ring, each of which is optionally substituted with halogen, OH, or (C1-C6)-alkyl, and one or more of the carbon atoms in the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or acyl groups of R2 to R10 is optionally replaced with a heteroatom selected from the group consisting of O, S, N, P and Si, which is optionally substituted with one or more groups selected from halogen, OH, and (C1-C6)-alkyl;
• LG represents any suitable leaving group.