Malassezin and analogs thereof as skin brightening agents
AssigneeVersicolor Technologies, LLC
InventorsMichael Einziger, Ann Marie Simpson
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Abstract
The present invention relates to compounds, compositions, and methods for brightening skin. The compounds, compositions, and methods of the present invention generally involve compounds produced by a Malassezia yeast, and chemical analogs thereof. In addition to skin brightening applications, the compounds, compositions, and methods of the present invention may be used to modulate melanocyte activity, induce melanocyte apoptosis, agonize an arylhydrocarbon receptor (AhR), improve hyperpigmentation caused by a hyperpigmentation disorder, and modulate melanin production, melanosome biogenesis, and melanosome transfer.
Claims4
A method for brightening skin in a subject comprising:
- contacting the subject with a compound having the structure of formula (II):
- wherein:
- R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are independently selected from the group consisting of hydrogen and methyl;
- or a crystalline form, hydrate, or cosmetically or pharmaceutically acceptable salt thereof.
A method for agonizing an arylhydrocarbon receptor (AhR) in a subject comprising:
- contacting the subject with a compound having the structure of formula (II):
- wherein:
- R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are independently selected from the group consisting of hydrogen and methyl;
- or a crystalline form, hydrate, or cosmetically or pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.