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US 2024/0252679 A1Published application
Recombinant adeno-associated virus having variant capsid, and application thereof
AssigneeShanghai Regenelead Therapies Co., Ltd.
InventorsWentao ZHANG, Cheng LIAO, Wei NING
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Abstract
Provided are a recombinant adeno-associated virus (rAAV) having a variant capsid, and an application thereof. Specifically, provided are a variant AAV capsid protein, an rAAV viral particle comprising the variant AAV capsid protein, and an application thereof in delivering a gene product to a cell (e.g., a retinal cell).
Claims21
A variant adeno-associated virus (AAV) capsid protein, comprising an inserted polypeptide relative to a parental AAV capsid protein, wherein the inserted polypeptide comprises a polypeptide selected from any one of 1)-6) or any combination thereof:
- 1)
- (SEQ ID NO:
- 12)
- LGDTTRP
- or
- (SEQ ID NO:
- 18)
- LALGDTTRPA;
- 2)
- (SEQ ID NO:
- 11)
- LAETTRP
- or
- (SEQ ID NO:
- 17)
- LALAETTRPA;
- 3)
- (SEQ ID NO:
- 13)
- LGETTRN
- or
- (SEQ ID NO:
- 19)
- LALGETTRNA;
- 4)
- (SEQ ID NO:
- 14)
- KADTTKN
- or
- (SEQ ID NO:
- 20)
- LAKADTTKNA;
- 5)
- (SEQ ID NO:
- 15)
- KDDTTRN
- or
- (SEQ ID NO:
- 21)
- LAKDDTTRNA;
- and
- 6)
- (SEQ ID NO:
- 16)
- LADTTKN
- or
- (SEQ ID NO:
- 22)
- LALADTTKNA.
46 more elements
Dependencies are inferred from the claim text.